Nimoy lent his voice as narrator to the 1994 IMAX documentary film, Destiny in Space, showcasing film-footage of space from nine Space Shuttle missions over four years time.
In 1999, he voiced the narration of the English version of the Sega Dreamcast game Seaman and promoted Y2K educational films.[46]
Together with John de Lancie, another actor from the Star Trek franchise, Nimoy created Alien Voices, an audio-production venture that specializes in audio dramatizations. Among the works jointly narrated by the pair are The Time Machine, Journey to the Center of the Earth, The Lost World, The Invisible Man and The First Men in the Moon, as well as several television specials for the Sci-Fi Channel. In an interview published on the official Star Trek website, Nimoy said that Alien Voices was discontinued because the series did not sell well enough to recoup costs.
In 2001, Nimoy voiced the role of the Atlantean King Kashekim Nedakh in the Disney animated feature Atlantis: The Lost Empire which featured Michael J. Fox voicing the lead role.
Nimoy provided a comprehensive series of voice-overs for the 2005 computer game Civilization IV. He did the television series Next Wave where he interviewed people about technology. He was the host in the documentary film The Once and Future Griffith Observatory, currently running in the Leonard Nimoy Event Horizon Theater at the Griffith Observatory in Los Angeles. Nimoy and his wife, Susan Bay-Nimoy, were major supporters of the Observatory's historic 2002–2004 expansion.[47]
In 2009 he voiced the part of "The Zarn", an Altrusian, in the television-based movie Land of the Lost, starring Will Ferrell.
Nimoy also provided voiceovers for the Star Trek Online massive multiplayer online game, released in February 2010,[48] as well as Kingdom Hearts Birth by Sleep as Master Xehanort, the series' leading villain. Tetsuya Nomura, the director of Birth by Sleep, stated that he chose Nimoy for the role specifically because of his role as Spock.
Nimoy was also a frequent and popular reader for "Selected Shorts", an ongoing series of programs at Symphony Space in New York City (that also tours around the country) which features actors, and sometimes authors, reading works of short fiction. The programs are broadcast on radio and available on websites through Public Radio International, National Public Radio and WNYC radio. Nimoy was honored by Symphony Space with the renaming of the Thalia Theater as the Leonard Nimoy Thalia Theater.